Welcome to Our St. Louis, MO Hotel When you're looking for hotels with a great location and Midwestern hospitality, choose the Holiday Inn Express St. Louis. Located on the doorstep of downtown in historic Lafayette Square, our St. Louis, MO hotel is close to the area's best sightseeing and businesses. Corporate travelers love staying with us because we offer amenities tailored to their needs, such as a 24-hour business center with Internet access, print and copy service. We are located minutes from area corporations, such as AT&T, Wells Fargo and Ralston Purina, as well as St. Louis University Hospital. Leisure travelers can take advantage of our location to visit Union Station and the iconic Gateway Arch, both of which are near our hotel's St. Louis address. You can enjoy a tour of St. Louis University, catch the Cards at Busch Stadium, take a riverboat ride or tour Anheuser-Busch Brewery. Don't miss Edward Jones Dome. Nearby Forest Park is home to major attractions, including MUNY Opera, Science Center, the St. Louis Zoo, Art Museum, History Museum and much more. As the "Smart Choice" for both leisure and business travelers visiting St. Louis, MO, our hotel boasts an indoor pool, a well-equipped fitness center and a free, hot breakfast. Additionally, our professional staff provides the friendliest, most efficient service around. Best of all, we have the name you trust at a price that fits your budget. Book your room today!