Choose the Holiday Inn St. Louis-Southwest Hotel Experience a memorable stay at our always-accommodating hotel with beautiful d cor in Southwest Saint Louis, Missouri. Our hotel's located off I-44 at exit 277B, putting you only 15 miles from the Lambert-St. Louis International Airport and 12 miles from downtown St. Louis. Our hotel's near numerous activities in the area including the St. Louis Zoo, Six Flags Amusement Park, Missouri Botanical Gardens, St. Louis Science Center and the Magic House. We are also only 12 miles from the famous Gateway Arch. And if you're a baseball fan, you can spend the day cheering on the St. Louis Cardinals at Busch Stadium, just 11 miles from the hotel. Our Saint Louis, Missouri hotel's location also benefits business travelers since we are within easy driving distance of local businesses like Liberty Mutual, Automated Data Processing (ADP), Maritz, Lutheran Church Missouri Synod, General Electric and the Fenton Business District. Staying with us means that you can have access to 19,079-square feet of flexible meeting space, a 24-hour business center and complimentary high-speed Internet access. Unlike other St. Louis hotel's in the area, we offer a quality name you can trust along with an array of amenities to guarantee a good stay. From our outdoor and indoor pools and whirlpool to our in-house restaurant, lounge and fitness center, we can meet your every need. Make your reservation today!