Stay at this Biloxi, Mississippi hotel featuring deluxe accommodations and southern hospitality. The Best Western Cypress Creek is conveniently located on the Mississippi Gulf Coast near the popular Casino row and many historic locations around Biloxi. Our hotel offers easy access to recreational opportunities including fishing, beaches and golf. Our hotel guests will also appreciate the variety of nearby dining and shopping options. Each spacious, well-appointed guest room features all the little extras that make a big difference while traveling such as high-speed Internet access, microwave and refrigerator. Other special hotel amenities include a complimentary deluxe continental breakfast, fitness room, outdoor pool, lighted tennis court, meeting rooms and banquet facilities. Whether spending the day sight-seeing or relaxing on the beach, our friendly staff is ready to ensure you a comfortable and memorable stay. Make an online reservation today at our Best Western Cypress Creek in Biloxi, Mississippi.