Our Vermillion Hotel is Close to USD At our hotel, you're right across the street from the University of South Dakota and only moments away from outdoor adventures on the Missouri River. The Holiday Inn Express Hotel & Suites Vermillion is situated just off Highway 50 and offers a convenient location for every traveler. Our facilities are ideal for corporate and government guests lodging in Vermillion, SD. Free Wi-Fi access makes working from the hotel quick and easy. Make your next event a success with our meeting room, which can accommodate up to 60 people. We're also near such businesses as Polaris and Masaba, and we're close to the National Guard. While you're here, make sure you see a game at USD's DakotaDome. Hotel guests also enjoy visiting the National Music Museum, a must-see for any musician or music lover; downtown Vermillion offers a wide variety of restaurants renowned for their quality like Raziel's and Carey's Bar. You can even follow in the footsteps of Lewis and Clark with a visit to Spirit Mound. Lodging in Vermillion, SD offers you an array of great amenities. Take a dip in the indoor pool or watch the stress melt away in our whirlpool. Keep up with your workout in a state-of-the-art Fitness Center. Every morning you can sit by the rustic fireplace and enjoy the hot, complimentary Express Start Breakfast Bar. These amenities combined with great service make our award-winning hotel a memorable place to stay.