Cairo Custom House, The (circa 1872) 14th and Washington Avenue, Cairo, IL 62914, 618-734-1019, Built after congress named Cairo a port of delivery, The Cairo Custom House is a unique and interesting attraction. 

Magnolia Manor 2700 Washington, Cairo, IL 62914, 618-734-0210, A 14 room Italianate style structure. 

Fort Defiance Route 51, Cairo, IL 62914, 618-734-2737, This was a Civil War post.

Cairo Public Library 1609 Washington Avenue, Cairo, IL 629914, 618-734-1840, This delightful community library offers a large selection of literature, periodicals and public access to computers. 

Safford Memorial Library 1609 Washington Avenue, Cairo, IL 62914, 618-734-1840, Built in Queen Anne architecture style.