Mrs. Clemen's Antique Mall 305 North Main Street, Hannibal, MO 63401, 573-221-6427, One of the largest antique malls in the area with over 60 booths. Ice cream available at open snack counter. 

Olde River Antiques 306 North Third, Hannibal, MO 63401, 573-221-2080, Specializing in art glass, art pottery, clocks, fine Victorian furniture, primitives, and collectibles. 

Picture Perfect Gallery & Framing 101 North Main Street, Hannibal, MO 63401, Corner of Main & Broadway, 573-221-4090, 888-749-7373, Offers creative custom framing & a gallery of Missouri and America's favorite artists. Specializing in Civil War art by Mort Kunstler & John Paul Strain. Gifts made in the U.S.include: glass oil candles; and Byer's Choice Carolers. Art related gifts include: collector plates, mugs, Christmas ornaments & coffee table art books by the artists they feature. They ship all over the U.S. Hours: Monday through Saturday, 10 a.m. - 5 p.m. central time. Voted the area's favorite art gallery, picture framer & gift shop five years in a row. more... 

Ayers Pottery 308 North Third Street, Hannibal, MO 63401, 573-221-6960, A unique shop featuring handmade Ayers Pottery, gourmet foods, works by local artists and more. 

Opened Book 606 Mark Twain Avenue, Hannibal, MO 63401, 573-221-6449, Features thousands of new and used books, paintings by local artists, beaded jewelry and unique creations. 

Hickory Stick 326 North Main Street, Hannibal, MO 63401, 573-221-4538, Three historic buildings with 2,000 bolts of fabric, quilting supplies, stamped embroidery & cross stitched quilt tops, unique buttons, large selection of wood & fabric craft patterns including redwork & primitive stitchery.  

Scrapbook Center, The 305 North Main Street, Hannibal, MO 63401, 573-221-6427, Find everything you need for scrapbooking. They have stickers, unique paper, chalk, albums and accessories.  

Wild Birds Unlimited 101 North Main Street, Hannibal, MO 63401, 573-221-3535, A nature shop specializing in backyard birdfeeding and garden accents. 

Mississippi Dry Goods 217 North Main Street, Hannibal, MO 63401, 573-221-1799, Stop by for an ice-cold coca cola, have some creamy fudge or rich chocolates and browse through this spacious shop for gifts, collectibles, antiques, primitives, and many "one of a kind items." 

Missouri House 303 North Main Street, Hannibal, MO 63401, 573-221-9118, Country shop features collectibles, handcrafted items and lots of seasonal decor. 

Pudd'NHeads 115 Bird, Hannibal, MO 63401, 573-248-1018, A unique shop full of handcrafted treasures, antiques, collectibles and sterling silver. 

Becky's Old Fashioned Ice Cream Parlor & Emporium 318 North Main, Hannibal, MO 63401, 573-221-0822, This store features old fashioned hand dipped ice cream cones, floats, shakes, and many other confections.  more... 

Mark Twain Book & Gift Shop 213 Hill Street, Hannibal, MO 63401, 573-221-2140, Large selection of history books, tapes, videos and souvenirs. 

Inspirations 221 North Main, Hannibal, MO 63401, 573-248-1665, Home Decor for todays life style. Inspirations for the home.  

Native American Trading Company & Gallery 115 North Main Street, Hannibal, MO 63401, Across from Mark Twain's Museum, 573-248-3451, Authentic hand crafted items from more than a dozen native American cultures. A Native American art gallery featuring Herman Adams. Minnetoka Moccasins. Cherokee herbals and much more.