Clinton House (circa 1765) 549 Main Street, Poughkeepsie, NY 12601, 914-471-1630, The Clinton House maintains archives and a library for local historical research, and was named for New York's first governor, George Clinton. 

Glebe House (circa 1767) 635 Main Street, Poughkeepsie, NY 12601, 845-454-0605, This house represents a modest home of the late 18th and early 19th centuries and is filled with period furnishings and antiques. 

Main Post Office 55 Mansion Street, Poughkeepsie, NY 12601, 914-452-3421, This early 20th century post office is a National Historic Landmark with famous murals and interesting architecture. 

Samuel F. B. Morse Historic Site 370 South Road, Poughkeepsie, NY 12601, 914-454-4500, Visit the home of artist and inventor of the telegraph and Morse Code, Samuel Morse. 

Smith Metropolitan AME Zion Church (circa 1836) 124 Smith Street, Poughkeepsie, NY 12601, 845-454-1913, Guided tours of this historic church provide information on the history of the church and its prominent parishioners, including the first woman ordained a Methodist deacon. Descriptions of the stained glass windows are also provided. 

Springside National Historic Site 185 Academy Street, Poughkeepsie, NY 12601, 845-471-0183, This site is recognized as the last surviving example of America's first native-born landscape architect, Andrew Jackson Downing, and is the first site in the City of Poughkeepie given federal recognition for its historic importance. Features include 20 acres of old carriage roads. 

Barrett Art Center 55 Noxon Street, Poughkeepsie, NY 12601, 914-471-2550, The Barrett Art Center features a gallery, workshops, lectures, and classes. It is part of the National Historic Register. more... 

Cunneen-Hackett Arts Center 9 and 12 Vassar Street, Poughkeepsie, NY 12601, 845-471-1221, Cunneen-Hacket is an art gallery promoting local artists. They also sponsor dancers, musicians, dramas, lectures, and films. 

Frances Lehman Loeb Art Center 124 Raymond Avenue, Poughkeepsie, NY 12604, located at Vassar College, 845-437-7745, This facility houses over 15,000 works of art from antiquity to modern day. more... 

Mid-Hudson Children's Museum 75 North Water Street, Poughkeepsie, NY 12601, 845-471-0589, A great destination for children to see fun and educational exhibits or play in the activity area. This is also an ideal place for field trips, offering traveling exhibits and play groups. 

Mill Street Loft 455 Maple Street, Poughkeepsie, NY 12601, 845-471-7477, Home to The Art Institute, this award-winning multi-arts educational center provides creative arts programs and classes to children and adults and features many exhibits in their art gallery. more...

River Boat Tours 310 Mill Street, Poughkeepsie, NY 12601, 914-473-5211, Enjoy exciting cruises on paddle wheeler, brunches, lunches, dinners, wine tasting, and private charters.