Greenhouse, The (circa 1894) 47 East Fifth Street, Chillicothe, OH 45601, 740-775-5313, Grand Queen Anne home, listed in the National Register of Historic Places, featuring a downstairs greenhouse and four guest rooms upstairs. Amenities include private baths, two line phones, and high speed Internet access.

Guest House, The (circa 1826) 57 West Fifth Street, Chillicothe, OH 45601, 740-772-2204, Greek Revival home offering five guest rooms, three in the main house and two in the original two story guest house, featuring private baths, cable television, and high speed Internet service. A full breakfast is served in the dining room, book and video libraries, and evening beverages are available to guests on their stay.

Murphin Ridge Inn 750 Murphin Ridge Road, Chillicothe, OH 45693, Located 48 Miles Southwest in West Union, 937-544-2263, Featuring breathtaking views of the foothills of the Appalachian Mountains, Murphin Ridge Inn is a Select Registry property situated on 142 acres of rolling woodland and farmland in Southwestern Ohio’s Amish country. The Guest House offers 10 uniquely furnished guest rooms. Each room features one or two queen-size beds, American 18th century reproductions, Shaker furniture hand-built by David T. Smith, a full private bath, and air conditioning. Some guest rooms come complete with fireplaces, private porches, and trundle beds. Each of the nine hand-built cabins, surrounded by large oak and maple trees, has a whirlpool tub, fireplace, queen or king-size bed, heating and air conditioning, and a front porch furnished with comfortable chairs. A country breakfast is served each morning.

Victoria Manor Bed and Breakfast (circa 1850's) 30 Western Avenue, Chillicothe, OH 45601, 740-775-6424, Located on two spacious acres, this Victorian home is decorated in Victorian and Colonial antiques and offers four guest rooms. The guest rooms feature private baths, color cable television, DVD or VCR players, coffee makers, wireless high-speed Internet, and toiletries. Amenities include an outdoor fitness area, fire pit, hammock built for two and a gazebo. A full breakfast is included on your stay.

Cut in the Hill 19334 State Route 327, Wellston, OH 45692, 740-887-5860, These cabins make a great gift idea for any occasion, any time of the year. Plenty to do while staying here including hiking, canoeing, rock climbing & rapelling, mountain biking, fishing, Putt Putt Golf, horse back riding, and a water adventure park.

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Best Western 1250 North Bridge Street, Chillicothe, OH 45601, 740-775-7000, The Best Western Adena Inn is the closest hotel to the outdoor drama 'Tecumseh' and minutes away from both the VA Hospital and Adena Medical Center. If shopping is in your plans, they are within walking distance of two shopping centers and two miles from downtown 'Historic Chillicothe'.  

Christopher Inn & Suites 30 North Plaza Boulevard, Chillicothe, OH 45601, 740-774-6835, Enjoy one of the 55 well appointed rooms including five two-room suites, a corporate apartment, an executive suite, and a deluxe honeymoon suite with jacuzzi. Amenities include wireless Internet, heated indoor pool, hot tub and a sauna. 

Comfort Inn 20 North Plaza Boulevard, Chillicothe, OH 45601, 740-775-3500, Features well-appointed rooms including executive kings, two room suites, and a corporate apartment. Amenities include an outdoor pool, business services, an on-site cocktail lounge, a continental breakfast, and access to an off-site fitness, tennis and racquetball facility.  

Comfort Inn Jackson 605 East Main Street, Jackson, OH 45640, 740-286-7581, Offers guest rooms featuring refrigerators, coffee makers, irons, ironing boards, massage showerheads and hair dryers. Near Apple Fest, Lake Hammertown, Trour Derby, and Wildlife Preserve. Horseback riding and swimming nearby. 

Hampton Inn & Suites 100 North Plaza Boulevard, Chillicothe, OH 45601, 740-773-1616, 800-HAMPTON, Offers 71 rooms including two room and fireplace suites and features an indoor pool, whirlpool and sauna, business center, fitness room. Extended deluxe Continental breakfast.  more... 

Holiday Inn Express 1003 East Main Street, Chillicothe, OH 45601, 740-779-2424, The Holiday Inn Express Chillicothe Hotel is located off the Main St. Exit, from Rt 35, 50 and 23 near Historical downtown & shopping. Features include an indoor pool, breakfast, high speed Internet access, guest laundry, and fitness center.