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Florence South Carolina Lodging

Hotels, Lodges, Extended Stay

  • Best Western Inn
    1808 West Lucas Street • Florence, SC 29501
    843-678-9292
    A variety of amenities are in all of the 74 tastefully decorated guest rooms at this hotel such as... more...  map

  • Comfort Inn
    1916 West Lucas Street • Florence, SC 29501
    843-665-4558
    A variety of spacious guest rooms with an array of great amenities are available at this hotel with... more...  map

  • Country Hearth Inn
    831 South Irby Street • Florence, SC 29501
    843-662-9421
    A wide variety of amenities are on site at this elegant hotel including a fitness center, an... more...  map

  • Country Inn & Suites
    1739 Mandeville Road • Florence, SC 29501
    843-317-6616
    Hotel features a continental breakfast, local calls, spacious guest rooms feature desk,... more...  map

  • Courtyard By Marriott
    2680 Hospitality Boulevard • Florence, SC 29502
    843-662-7066
    Relax in one of the 90 beautifully appointed guest rooms at this hotel with all rooms including... more...  map

  • Days Inn
    2111 West Lucas Street • Florence, SC 29501
    843-665-4444
    One king sized bed or two queen sized beds are in all of the 103 spacious guest rooms at this hotel... more...  map

  • Days Inn Lake City
    170 South Ron McNair Boulevard • Lake City, SC 29560
    843-394-3269
    Days Inn of Lake City SC is located on Highway 52, accessible from Rt 378 off I-95. They are a family friendly motel in a quite, peaceful area within walking distance to our downtown shops. They have a beautiful outdoor pool, high speed internet access, and a continental breakfast each morning.  map

  • Days Inn South
    3783 West Palmetto Street • Florence, SC 29501
    843-665-8550
    There are 120 comfortably appointed guest rooms at this hotel that offers microwaves and refrigerators in some of the rooms upon request and irons and ironing boards at the front desk. A full service restaurant that serves delicious country cuisine is on site, as well as an outdoor swimming pool and Jacuzzi. Golf packages are available and guests receive a pass to a nearby tennis court.  map

  • Econo Lodge North
    1811 West Lucas Street • Florence, SC 29501
    843-665-8558
    This hotel offers guests a delicious continental breakfast, ocal calls an indoor heated pool with... more...  map

  • Fairfield Inn Florence
    140 Dunbarton Drive • Florence, SC 29501
    843-669-1666
    All of the 135 spacious and comfortable guest rooms at this hotel have work desks with lamps, data... more...  map

  • Guesthouse International
    2001 West Lucas Street • Florence, SC 29503
    843-669-1921
    The GuestHouse International Inn is a beautiful property located on 7 acres of spacious, landscaped... more...  map

  • Hampton Inn & Suites Florence North I-95
    1735 Stokes Road • Florence, SC 29501
    843-662-7000
    The Hampton Inn & Suites Florence North I-95 is just off I-95 and offers many amenities like a hot... more...  map

  • Hampton Inn & Suites Florence-Civic Center
    3000 Radio Drive • Florence, SC 29501
    Adjacent to the Florence Civic Center
    843-629-9900
    Beautiful three story, award-winning hotel that offers standard guest rooms with one king sized bed... more...  map

  • Holiday Inn Express Hotel & Suites
    2101 Florence Harlee Boulevard • Florence, SC 29506
    843-629-9779
    This four-story, interior corridor hotel boasts 86 guest rooms & suites. It offers a heated indoor... more...  map

  • Holiday Inn Hotel & Suites
    1819 West Lucas Street • Florence, SC 29501
    843-665-4555
    Full service hotel that offers 204 luxuriously appointed guest rooms and suites with all rooms... more...  map

  • Howard Johnson Express Inn
    3821 Bancroft Road • Florence, SC 29501
    843-664-9494
    An Award Winning, AAA approved property, this hotel is a perfect stopping point between Florida and... more...  map

  • Microtel Inn
    1912 Enterprise Drive • Florence, SC 29502
    843-629-9523
    This property proudly offers a central location near area businesses and attractions. The... more...  map

  • Ramada Inn
    2038 West Lucas Street • Florence, SC 29501
    Intersection of Interstate Hwy. 95 & U.S. Hwy. 52
    843-669-4241
    A variety of standard amenities are found in the 179 graciously inviting and spacious guest rooms... more...  map

  • Red Roof Inn
    2690 David McLeod Boulevard • Florence, SC 29501
    843-678-9000
    Easily accessible from I-95 and I-20, the Florence Red Roof Inn is within walking distance of many... more...  map

  • Sleep Inn
    1833 Florence Park Drive • Florence, SC 29502
    843-662-8558
    Award-winning hotel that offers spacious and comfortable guest rooms with microwaves,... more...  map

  • Springhill Suites By Marriott
    2670 Hospitality Boulevard • Florence, SC 29501
    843-317-9050
    SpringHill Suites, Marriott's new moderately priced all-suites hotel, designed for guest who want... more...  map

  • Suburban Extended Stay
    1914 West Lucas Street • Florence, SC 29501
    843-665-2575
    The Suburban Extended Stay Florence hotel offers a great location, wonderful amenities and... more...

  • Super 8 Motel
    1832 1/2 West Lucas Street • Florence, SC 29501
    843-661-7267
    This convenient property features a long list of modern amenities. Guests enjoy a delicious SuperStart Breakfast each morning and a location right next to restaurants.  map

  • Wingate Inn
    2123 West Lucas Street • Florence, SC 29501
    843-629-1111
    You'll find 84 oversized, comfortable guest rooms at this hotel with all rooms including king sized... more...  map

Bed & Breakfast, Cabins & Cottages

  • Florence, SC, on VRBO®
    Renting a private vacation home offers the affordability, exceptional value, and personal attention that you deserve. Most private vacation homes offer considerably more space than you will find in the typical hotel room often at a reduced cost. Now, families can vacation together and still have room to breathe. View their list of vacation rentals now...

  • Ambrias Garden Manor Bed and Breakfast (circa 1920)
    111 Kuker Street • Florence, SC 29501
    843-661-6060
    Ambrias Garden Manor sits just ten minutes or less from both I-95 and I-20, as well as only one... more...  map

Lodging Guides and Directories

  • BedandBreakfast.com
    is a leading directory of bed and breakfasts, inns, and boutique lodgings throughout neighboring South Carolina towns. Shop, compare, and book from their large selection of B&B properties with many exclusive deals offered. Gift certificates are also available. BedandBreakfast.com has nearly 7,000 property listings throughout the United States with 50,000 reviews, 80,000 property photos, and interactive maps.

Condos & Vacation Rentals

  • Florence, SC,Vacation Rentals By Owner on VRBO®
    Renting a private vacation home offers the affordability, exceptional value, and personal attention that you deserve. Most private vacation homes offer considerably more space than you will find in the typical hotel room often at a reduced cost. Now, families can vacation together and still have room to breathe. View their list of vacation rentals now...

  • HomeAway Vacation Rentals in Florence, SC
    Forget ordinary hotel rooms! Finding the perfect vacation getaway in Florence, SC is easy on HomeAway.com. Choose from 75,000 homes, condos, guesthouses, cottages, and cabins worldwide, and inquire directly with property owners through the site. HomeAway.com vacation rentals offer a unique local experience, often less expensive and more spacious than hotel rooms.

R.V. Parks & Camping

  • Florence KOA Campground
    1115 East Campground Road • Florence, SC 29506
    843-665-7007
    Year round quiet and relaxing campground that offers all pull through sites with your choice of... more...  map

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