Orangeburg South Carolina Lodging

Hotels, Lodges, Extended Stay

• Comfort Inn & Suites
  3671 Saint Matthews Road • Orangeburg, SC 29115
  803-531-9200
  The Comfort Inn & Suites is conveniently located less than one mile from the Orangeburg Regional... more...  map

• Days Inn North
  3691 St. Matthews Road • Orangeburg, SC 29115
  803-531-2590
  Relax in one of the 216 beautifully decorated guest rooms at this hotel with all rooms having... more...  map

• Fairfield Inn
  663 Citadel Road • Orangeburg, SC 29115
  803-533-0014
  A wide variety of thoughtful amenities are in all of the 65 comfortable guest rooms at this room... more...

• Hampton Inn
  3583 St. Matthews Road • Orangeburg, SC 29118
  Close to the Regional Medical Center
  803-531-6400
  Beautifully appointed two story hotel that features 69 lovely guest rooms with either king sized or... more...  map

• Holiday Inn Express Hotel & Suites Orangeburg, Sc
  118 Sleep Inn Road • Orangeburg, SC 29118
  803-539-2900
  Welcome to Orangeburg, the Garden City of South Carolina and home of Edisto Memorial Gardens.... more...  map

• Howard Johnson Express Inn
  3608 Old St. Matthews Road • Orangeburg, SC 29115
  803-531-4900
  Conveniently located off I-26, Exit 145A, 35 miles southeast of Columbia and 75 miles northwest of... more...  map

• Jameson Inn
  2350 Chestnut Street Northeast • Orangeburg, SC 29115
  Off Highway 601 behind Applebess
  803-534-1611
  Take advantage of amenities such as work desks, data ports, fitness centers, pools, a deluxe... more...  map

• Orangeburg - Days Inn South
  Route 2 Box 215 • Orangeburg, SC 29115
  803-534-0500
  Days Inn Conveniently Located Off I-26 Close between Columbia, SC and Charleston, SC. Easy access I-26 Exit 154B(US 301) Quiet and Relaxing, Restaurant on Property. Just the right place to stay after a long day of driving Directly off of the interstate to the property Check in, have Dinner, relax for a good nights sleep Up in the morning, have Breakfast, in our Restaurant Check-out and back on the I-26 to finish your trip Charleston,South Carolina-55 miles Savannah, Georgia is only 110 miles ...  map

• Quality Inn & Suites
  1415 John C. Calhoun Drive • Orangeburg, SC 29115
  803-531-4600
  The only full service hotel in Orangeburg, this hotel offers 141 beautifully appointed guest rooms... more...  map

• Sleep Inn
  3689 St. Matthews Road • Orangeburg, SC 29115
  803-531-7200
  Sleep Inn offers interior Corridor rooms, PC hookups, 25in TV, and desk in all rooms. Guest laundry... more...  map

• Super 8 Motel
  610 John Calhoun Drive • Orangeburg, SC 29115
  803-531-1921
  The Super 8 of Orangeburg offers guests a delicious continental breakfast. It is located within... more...  map

Bed & Breakfast, Cabins & Cottages

• Orangeburg, SC, on VRBO®
  Renting a private vacation home offers the affordability, exceptional value, and personal attention that you deserve. Most private vacation homes offer considerably more space than you will find in the typical hotel room often at a reduced cost. Now, families can vacation together and still have room to breathe. View their list of vacation rentals now...

• Thee Matriarch Bed & Breakfast and Meeting & Event
  1170 Fischer Street • Orangeburg, SC 29115
  803-531-6226
  Thee Matriarch Bed & Breakfast and Meeting and Event Venue is located in the heart of historic... more...  map

Bed & Breakfast Guides and Directories

• BedandBreakfast.com
  is a leading directory of bed and breakfasts, inns, and boutique lodgings throughout neighboring South Carolina towns. Shop, compare, and book from their large selection of B&B properties with many exclusive deals offered. Gift certificates are also available. BedandBreakfast.com has nearly 7,000 property listings throughout the United States with 50,000 reviews, 80,000 property photos, and interactive maps.

Condos & Vacation Rentals

• Orangeburg, SC,Vacation Rentals By Owner on VRBO®
  Renting a private vacation home offers the affordability, exceptional value, and personal attention that you deserve. Most private vacation homes offer considerably more space than you will find in the typical hotel room often at a reduced cost. Now, families can vacation together and still have room to breathe. View their list of vacation rentals now...

• HomeAway Vacation Rentals in Orangeburg, SC
  Forget ordinary hotel rooms! Finding the perfect vacation getaway in Orangeburg, SC is easy on HomeAway.com. Choose from 75,000 homes, condos, guesthouses, cottages, and cabins worldwide, and inquire directly with property owners through the site. HomeAway.com vacation rentals offer a unique local experience, often less expensive and more spacious than hotel rooms.