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Best Western Inn 355 Nye Road, Wytheville, VA 24382, 276-228-7300, This hotel provides 100 comfortably appointed guest rooms, all with data ports, coffee makers, hair dryers, irons, and ironing boards. Rooms with microwaves and refrigerators are also available. An outdoor pool is on the property for guests to enjoy and a continental breakfast is served daily. 

Comfort Inn 315 Holston Road, Wytheville, VA 24382, 276-228-4488, Surrounded by mountain views, this hotel provides comfortably appointed guest rooms, all with wireless high speed Internet access, hair dryers, coffee makers, irons, and ironing boards. Some of the rooms have microwaves and refrigerators. Guests can enjoy a seasonal outdoor pool, 24 hour coffee and tea in the lobby, and a daily superior breakfast bar with hot items while staying here. 

Comfort Inn Max Meadows 2594 East Lee Highway, Wytheville, VA 24382, Max Meadows, Virginia, 276-637-4281, Ideally located at the intersection of Interstate 77 and Interstate 81, this hotel provides elegantly appointed guest rooms, all with coffee makers, irons, ironing boards, hair dryers, and Serta Comfort Sleepers. An indoor heated pool and an exercise room are on the property for guests to enjoy and a deluxe continental breakfast is served each morning.

Days Inn 150 Malin Drive, Wytheville, VA 24382, 276-228-5500, There are 118 spacious and comfortable guest rooms available at this hotel that features hair dryers and data ports in all of the rooms. A technologically advanced business center is on the property and a continental breakfast is served every morning. 

Econo Lodge 1160 East Main Street, Wytheville, VA 24382, 276-228-5517, This hotel is nestled in the Blue Ridge and Allegheny Mountains. You can relax and enjoy the beautiful mountain range and if you are an early riser, the beautiful sunrises. All rooms are equipped with coffee maker and safe. A continental breakfast is served each morning. 

Hampton Inn 1090 Peppers Ferry Road, Wytheville, VA 24382, 276-228-6090, There are 68 spacious and comfortable guest rooms, including suites with Jacuzzis, microwaves, and refrigerators, available at this hotel that also features an outdoor pool and meeting and banquet facilities. Guests can enjoy a continental breakfast each morning while staying here.

Holiday Inn 1800 East Main Street, Wytheville, VA 24382, 540-228-5483, Nestled in the beautiful Blue Ridge Mountains of Southwest Virginia, this hotel offers 199 spacious and comfortable guest rooms, all with hair dryers, irons, ironing boards, and coffee makers. Amenities on site for guests to enjoy include a full service restaurant, outdoor pool, room service, and dry cleaning services. 

Quality Inn & Suites 2015 East Main Street, Wytheville, VA 24382, 276-228-4241, Providing affordable rates and comfortable accommodations, this hotel features coffee makers, irons, ironing boards, hair dryers, and wireless high speed Internet access in all of the well appointed guest rooms. Some rooms also have refrigerators and microwaves. A continental breakfast is served every morning. 

Ramada Inn 955 Pepper's Ferry Road, Wytheville, VA 24382, 276-228-6000, This hotel features 154 comfortably appointed guest rooms, all with irons, ironing boards, coffee makers, and hair dryers. Many amenities are on site, including a full service Country Kitchen Restaurant, a cocktail lounge, large seasonal outdoor pool, room service, laundry valet services, and meeting and banquet facilities.

Sleep Inn 135 Nye Circle, Wytheville, VA 24382, 276-625-0667, A great place for business and leisure travelers, this hotel is nestled in the perfect location with convenient access to area attractions. Beautifully appointed guest rooms, an exercise room, and a daily continental breakfast are just some of the amenities guests can enjoy while staying at this hotel.  

Super 8 Motel 130 Nye Circle, Wytheville, VA 24382, 276-228-6620, Super 8 Motel is near area attractions, dining, and shopping. The guest rooms are nicely appointed and a delicious SuperStart Breakfast is served each morning. 

Travelodge 140 Lithia Road, Wytheville, VA 24382, 540-228-3188, This conveniently located property boasts 64 comfortably appointed guest rooms some with mountain views. A deluxe continental breakfast is served daily. All rooms feature coffeemaker, hairdryer, iron and ironing board, and clock radio, and cable TV with HBO.