McDowell House & Apothecary Shop 125 South Second Street, Danville, KY 40422, 859-236-2804, Dr. Ephraim McDowell made medical history here on Christmas morning 1809 with the first successful removal of an ovarian tumor. In a personally guided tour, you will hear the story of Dr. Ephraim McDowell, pioneer surgeon, and see this meticulously restored home, medical office and gardens.  

Constitution Square State Historic Site 134 South Second Street, Danville, KY 40422, 859-239-7089, This is the birthplace of Kentucky's statehood with ten constitutional conventions taking place at this site between 1784 and 1792. The park includes the first post office west of the Alleghenies, Governor's Circle, meetinghouse, courthouse, and jail. 

Jacobs Hall & Museum 303 South Second Street, Danville, KY 40422, 859-236-5132, The first state-supported school for the deaf founded in 1823, Jacobs Hall is located on the campus of Kentucky School for the Deaf. This restored Italianate structure features a historical re-creation of an 1850's student dorm and class room. 

John W. D. Bowling Model Train Museum 406 Maple, Danville, KY 40422, 859-236-8954, This museum showcases the railroads' importance in America, using Whimsical Miniatures. It has 2,600 linear feet of track and features a Kentucky autumn landscape of the 1950s.